Impingement Jets Mixing Skids for lipid nanoparticle production

Customized impingement jets mixing skid for Large Production Scale

The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be configured with up to eight parallel mixing units depending on customer requirements. Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer.

The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.

Impingement jets mixing skid for Small Production Scale

The Impingement Jets Mixing (IJM) Small Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) contains two parallel mixing units. Each unit consists of four pumps enabling all the steps from predilution of the concentrated Active Pharmaceutical Ingredient (API), Impingement Jets Mixing of lipid and API phase, and finally the quenching of the nanoparticle solution. Furthermore, each unit is equipped with four flowmeters for flow monitoring, one jets mixer, and two mixers for predilution and quenching.

All skids are built in a stainless-steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.

Impingement jets mixing skid for Pilot Scale

The Impingement Jets Mixing (IJM) Pilot Scale Unit for high-flow production of nanoparticles (LNP, microemulsions, etc.) is the perfect choice for R&D purposes and small productions batches.

The unit contains of four pumps enabling all the steps from predilution of the concentrated Active Pharmaceutical Ingredient (API), Impingement Jets Mixing of lipid and API phase and finally the quenching of the nanoparticle solution.

Furthermore, the unit is equipped with four flowmeters for flow monitoring, one jets mixer and two mixers for predilution and quenching.

The skid is built in a stainless-steel frame on casters and are suitable for CIP cleaning procedure in pharmaceutical production.

IJM NanoScaler: a benchtop system for lipid nanoparticle formulation

KNAUER’s new benchtop IJM NanoScaler system is designed for lipid nanoparticle R&D – allowing scientists to screen for the optimal process parameters for the formulation of API-containing lipid nanoparticles.

The IJM NanoScaler is made with research and development and lab-scale production in mind.

Equipped with our lipid nanoparticle producing Impingement Jets Mixing (IJM) technology the NanoScaler allows researchers to determine the optimum encapsulation conditions for their mRNA based therapy before scaling up the process to run on a larger GMP-compliant IJM NanoProducer unit.

The NanoScaler is made for low sample consumption so as not to waste valuable API. Its small footprint means it can comfortably sit on the benchtop of a research and development lab. The system comes with five different KNAUER Impingement Jets Mixers to help researchers determine which conditions result in the optimum level of nucleotide encapsulation. In addition, researchers can use their own custom mixing unit and benefit from the flexibility of the system set-up.

• Flexible system with choice of Impingement Jets Mixers
• Determine the best conditions for your therapy formulation.
• Produce LNP formulations from 1ml to hundreds of millilitres.
• Perfect for proof-of-concept testing and pre-clinical trial