Impingement Jets Mixing Skids For The Production Of Lipid Nanoparticles

Customised Mixing Skids For Large Production Scale

The Impingement Jets Mixing (IJM) Large Production Scale units are designed to support the manufacturing of lipid nanoparticles and microemulsions, for example. Each unit can be configured with up to eight parallel mixing units, depending on the customer’s requirements. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical productions. 

One skid consists of:

• Two pumps – delivering API and lipid streams.
• Two flowmetres – for flow control.
• One jet mixer. 

The above elements can be adapted to meet required conditions and scale, with the number of parallel units depending on the application.

Impingement Jets Mixing Skids For Small Production Scale

These Small Productions Scale units contain two parallel mixing units, ideal for the high-flow production of lipid nanoparticles, microemulsions, and other nano structures. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production settings. 

One skid consists of:

• Four pumps – enabling all steps from predilution of the concentrated Active Pharmaceutical Ingredient (API), Impingements Jets Mixing of the lipid and API phase and, finally, the quenching of the nanoparticle solution
• Four flowmetres – for flow monitoring
• One jet mixer
• Two mixers – for predilution and quenching.

Impingement Jets Mixing Skids For Pilot Scale

The IJM Pilot Scale units are perfect for research and development, and small production batches of lipid nanoparticles, microemulsions, and other structures. Each skid is built in a stainless steel frame on casters and is suitable for CIP cleaning procedures in pharmaceutical production settings.

One unit contains:

• Four pumps – enabling all the steps from predilution of the concentrated Active Pharmaceutical Ingredient (API), Impingement Jets Mixing of the lipid and API phase and, finally, the quenching of the nanoparticles. 
• Four flowmetres – for flow monitoring.
• One jet mixer.
• Two mixers – for predilution and quenching.

IJM NanoScaler For Formulation Of Lipid Nanoparticles

The IJM NanoScaler is KNAUER’s new benchtop system designed for the research and development of lipid nanoparticles. This product is made with R&D and lab-scale production in mind, allowing scientists to screen for the optimal process parameters for the formulation of API-containing lipid nanoparticles.

Equipped with our lipid nanoparticle producing IJM technology, the NanoScaler allows researchers to determine the optimum encapsulation conditions for their mRNA-based therapy. This then allows them to scale up the process to run on a larger, GMP-compliant IJM NanoProducer unit.

Benefits Of The KNAUER NanoScaler

• Low Sample Consumption: Helps to avoid waste of valuable API.
• Small Footprint: The unit can comfortably sit on the benchtop of a research and development lab.
• Features: The system features five different KNAUER Impingement Jets Mixers to help researchers determine which conditions result in the optimum level of nucleotide encapsulation.
• Flexibility: Researchers can use their own custom mixing unit and benefit from the system’s flexible set-up.
• Volume: Produce liquid nanoparticle solutions ranging from 1 millilitre to hundreds of millilitres.
• Adaptability: These skids are perfect for proof-of-concept testing and pre-clinical trials.