Products and SolutionsDevelopment and Optimisation of LNP Formulations – Utilising the KNAUER NanoScaler
This application note outlines the use of KNAUER’s innovative Impingement Jets Mixing (IJM) benchtop system for formulating lipid nanoparticles (LNPs) with suitable size and polydispersity index (PdI) for various nucleic acid payloads.
The authors conducted measurements of Z-average size and polydispersity index for lipid nanoparticles created by IJM and microfluidic herringbone mixers to evaluate formulation reproducibility and efficiency. The findings also include transfection outcomes.
Application Details:
- Method: Lipid nanoparticle formulation (encapsulation)
- Mode: Impingement jets mixing versus microfluidic herringbone mixing
- Substances: mRNA, pDNA
Key Words: LNP, lipid nanoparticles, mRNA, pDNA, encapsulation efficiency, API, comparison, impingement jets mixing, herringbone microfluidic mixing, Z-average, PdI
Version: 2022 Download the application for Development and Optimization of LNP Formulations – Using the KNAUER NanoScaler at
https://www.knauer.net/Application/application_notes/VPH0076_Development_and_Optimization_of_LNP.pdf
For further information, please visit our website: https://verulamscientific.com/knauer-impingement-jets-mixing-skids/
As the official UK distributor for KNAUER, the Verulam Scientific team are available to address any enquiries you might have regarding LNP formulations. Feel free to call us at 01234 381000 or email [email protected].
