The online coupling of electrochemistry with mass spectrometry has shown great potential for the investigation of drug metabolism in pharmaceuticals and for structure elucidation of biopharmaceuticals and proteins.
In proteomics and protein chemistry ROXY Reactors are mainly used for reduction of disulphide bridges for the assignment of disulphide bonds in biopharmaceuticals, and for adduct formation such as drug-protein binding.
In pharma, ROXY Reactors are mainly used for synthesis, and oxidative metabolism studies. Drug and xenobiotic metabolites are formed instantaneously in the electrochemical cell, mimicking the enzymatic biotransformation of the Cytochrome P450 reactions that usually take place in the liver (Phase I reaction). Hereby, Electrochemistry becomes a truly biomimetic tool for enzymatic REDOX reactions.