ANTEC SCIENTIFICElectrochemical Reactors for Mass Spectrometry (MS) & Synthesis

Learn more about available electrochemical reactors from Antec Scientific for mass spectrometry and synthesis. Discuss your requirements with a member of the Verulam Scientific team using the link below to find the optimal instrument for your requirements.

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Elegantly Join Electrochemistry and Mass Spectrometry (MS)

The online coupling of electrochemistry with mass spectrometry has shown great potential for the investigation of drug metabolism in pharmaceuticals and for structure elucidation of biopharmaceuticals and proteins.

Applications

In proteomics and protein chemistry ROXY Reactors are mainly used for reduction of disulphide bridges for the assignment of disulphide bonds in biopharmaceuticals, and for adduct formation such as drug-protein binding.

In pharma, ROXY Reactors are mainly used for synthesis, and oxidative metabolism studies. Drug and xenobiotic metabolites are formed instantaneously in the electrochemical cell, mimicking the enzymatic biotransformation of the Cytochrome P450 reactions that usually take place in the liver (Phase I reaction).

Hereby, Electrochemistry becomes a truly biomimetic tool for enzymatic REDOX reactions.

Electrochemical Reactors for MS & Synthesis

Reactors for Proteomics

Antibody Engineering
Disulphide Bond Reduction

Reactors for Drug Metabolism

Drug and Xenobiotic Metabolism
Mimicking phase 1 and 2 Metabolism
Oxidative Metabolism
Automated Screening on REDOX reactions

Environmental Degradation

Degradation of POPs
Oxidative Transformation of Synthesis of TP’s
Waste and Drinking Water

Lipidomics / Lipid Oxidation

Cholesterol
Oxysterol
Phospholipids
Fatty Acid Methyl Esters (FAME)

Reactors for Synthesis

Electrochemical Synthesis of Metabolites / Degradants
Synthesis of µlg Quantities
Scale-up

Available Instrumentation

ROXY Exceed for EC-MS

Suitable for on- and off-line EC-MS
Fully programmable DC, Scan and Pulse mode
Compatible with all LC-MS systems

The ROXY™ Exceed is a new generation Potentiostat dedicated for coupling Electrochemistry with Mass Spectrometry (EC-MS). In on-line mode the ROXY Exceed can be used in direct infusion mode, for flow injection analysis, or with any type of LC-MS system. Applications and publications are available for using the ROXY in HDX-MS, top-down or bottom-up LC-MS proteomics. In off-line mode the ROXY Exceed is mainly used for electrochemical synthesis and for the collection of electrochemically generated products. Collected fractions are used for further analysis.

The Potentiostat is based on state-of-the-art electronics. It has a large voltage and current range of ± 4.9 V and 1 nA – 100 mA, respectively. It supports different modes of operation, DC, Scan, and Pulse for highest yields under the most challenging applications. The Exceed can be controlled via a contact closure from any LC-MS system by using Dialogue (Antec Scientific) or Chromeleon™ CDS (Thermo Fisher Scientific) software.

Download ROXY Exceed Potentiostat for EC-MS

Download ROXY Exceed Brochure

What Do Our Customers Say?

At Verulam Scientific, we are proud to have partnered with institutions across the UK, delivering bespoke solutions to suit unique requirements. Take a look below at what some of our previous customers have to say about a partnership with one of the UK’s leading suppliers of electrochemical reactors.

TESTIMONIALS

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FAQs

How Are Electrochemical Reactors Used In Drug Metabolism Studies?

Electrochemistry (EC) is a classical method for inducing oxidation reactions, making it a natural choice for simulating drug metabolism. Electrochemical flow-through cells, coupled on-line with analytical techniques such as mass spectrometry (MS) and optionally liquid chromatography (EC-LC-MS or EC-MS), have become the preferred method for these simulations. This approach provides comprehensive information regarding the nature of electrochemically-generated metabolites.

What Advantages Do Electrochemical Reactions Offer Compared To Traditional Synthesis Methods?

There are a number of benefits of electrochemical reactions compared to traditional methods, including:

Electrochemical reactions tend to exhibit good functional group tolerance
Reactions are carried out under milder conditions
More energy-efficient
Shorter reaction times for electrochemical reactions
Electrochemical reactions can be stopped at any point by turning off the switch
Electrochemical reactions can be easily scaled up

Can Electrochemical Reactors Simulate Oxidative Metabolism In Pharmaceuticals?

Yes, numerous studies have shown that electrochemical methods can effectively replicate specific oxidative metabolism processes.

How Can I Place An Order With Verulam?

To place an order for an electrochemical reactor, simply contact us by email, phone, or fill in a contact form. A member of our expert team will be happy to assist and provide you with more information to select the ideal instrument for your purposes.