HTX TechnologiesSAMPLE PREPARATION SOLUTIONS FOR MASS SPECTROMETRY IMAGING

People and Innovation in Molecular Imaging

MALDI Sample Preparation

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HTX M3+ Sprayer with heated nozzle and integrated pump

HTX M3+ Sprayer

The HTX M3+ Sprayer is based on a patented spray nozzle design.  Originally developed to deposit “hard-to-dissolve” polymers onto sample plates the unique spray technology is well suited for matrix deposition.  The unique combination of heat (the nozzle can be temperature controlled up to 140 C), pressure (carrier solvent is delivered at high pressure by an isocratic pump) and drying sheath gas (Dry Air or Nitrogen) result in a precisely controlled solvent/matrix deposition that can be used for many matrix types.

Thanks to its advanced design, the spray nozzle delivers matrix solution from <10 µL/min to 0.250 mL/min without the frequent clogging associated with other technologies.  In addition, the spray nozzle offers several ways to control spray characteristics including:

  • Spray flow rate
  • Spray Nozzle movement and velocity
  • Spray temperature
  • Spray drying time
  • Spray composition

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    HTX M5 Sprayer

    The HTX M5 Sprayer builds on the proven capabilities of its predecessor, the HTX TM-Sprayer, to offer even greater performance. The all-innovative M5 Sprayer with high velocity stage and heated sample holder drawer contribute to a greater user experience and expanded process capabilities.

    • New heated tray

    • 4x Faster nozzle

    • Newly designed chassis

    • Variable nozzle height

    • Greatest range of applications

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      HTX Sublimator

      An automated MALDI matrix deposition system offering speed, reproducibility, and the smallest available crystals for sub-micron resolution mass spectrometry imaging.

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      HTX AN-49

      Solvent-free matrix deposition via sublimation offers several advantages over typical spraying methods. It can often improve image resolution, as no solvent is ever introduced to the surface sample to induce analyte delocalization.

      • HTX AN-49 Improved image resolution and signal sensitivity of small molecules.
      • Validated protocols are available for DHB, CHCA, SA, DAN, 9-AA, and Norhamane.
      • Custom Vacuum Chamber – The HTX Sublimator features a rectangular vacuum chamber that achieve sublimation conditions extremely quickly to maximise efficiency for imaging MS sample preparation.
      • Timer Controlled Sublimation Step – Electronic controls and pre-defined matrix deposition protocols ensure sample-to-sample reproducibility and optimum matrix surface quality.

      HTX AN-50

      HTX AN-50 – MALDI MSI of Fingerprints

      Matrix assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) allows for the generation of molecular maps from a variety of materials. While MALDI MSI has thus far been most heavily utilized in the fields of pharmacology, analytical chemistry, and “omics” level studies, this technology offers tremendous opportunities in the field of forensic science as well.

      • Validated protocols are available for DHB, CHCA, SA, DAN, 9-AA, and Norhamane.
      • Custom Vacuum Chamber – The HTX Sublimator features a rectangular vacuum chamber that achieve sublimation conditions extremely quickly to maximise efficiency for imaging MS sample preparation.
      • Timer Controlled Sublimation Step – Electronic controls and pre-defined matrix deposition protocols ensure sample-to-sample reproducibility and optimum matrix surface quality.
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      Request a HTX Sublimator Brochure

        Contact Us

        If you would like further information on sample preparation solutions for mass spectrometry imaging, please fill in the form below and one of the team will be in touch.