HTX TechnologiesSAMPLE PREPARATION SOLUTIONS FOR MASS SPECTROMETRY IMAGING
People and Innovation in Molecular Imaging
MALDI Sample Preparation
HTX M3+ Sprayer with heated nozzle and integrated pump
HTX M3+ Sprayer
The HTX M3+ Sprayer is based on a patented spray nozzle design. Originally developed to deposit “hard-to-dissolve” polymers onto sample plates the unique spray technology is well suited for matrix deposition. The unique combination of heat (the nozzle can be temperature controlled up to 140 C), pressure (carrier solvent is delivered at high pressure by an isocratic pump) and drying sheath gas (Dry Air or Nitrogen) result in a precisely controlled solvent/matrix deposition that can be used for many matrix types.
Thanks to its advanced design, the spray nozzle delivers matrix solution from <10 µL/min to 0.250 mL/min without the frequent clogging associated with other technologies. In addition, the spray nozzle offers several ways to control spray characteristics including:
- Spray flow rate
- Spray Nozzle movement and velocity
- Spray temperature
- Spray drying time
- Spray composition
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HTX M5 Sprayer
The HTX M5 Sprayer builds on the proven capabilities of its predecessor, the HTX TM-Sprayer, to offer even greater performance. The all-innovative M5 Sprayer with high velocity stage and heated sample holder drawer contribute to a greater user experience and expanded process capabilities.
• New heated tray
• 4x Faster nozzle
• Newly designed chassis
• Variable nozzle height
• Greatest range of applications
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Solvent-free matrix deposition via sublimation offers several advantages over typical spraying methods. It can often improve image resolution, as no solvent is ever introduced to the surface sample to induce analyte delocalization.
- HTX AN-49 Improved image resolution and signal sensitivity of small molecules.
- Validated protocols are available for DHB, CHCA, SA, DAN, 9-AA, and Norhamane.
- Custom Vacuum Chamber – The HTX Sublimator features a rectangular vacuum chamber that achieve sublimation conditions extremely quickly to maximise efficiency for imaging MS sample preparation.
- Timer Controlled Sublimation Step – Electronic controls and pre-defined matrix deposition protocols ensure sample-to-sample reproducibility and optimum matrix surface quality.
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If you would like further information on sample preparation solutions for mass spectrometry imaging, please fill in the form below and one of the team will be in touch.
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