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HUDSON ROBOTICSAutomated Liquid Handling Systems
Streamlining workflows in the life sciences
Hudson’s automated liquid handling systems are designed to streamline laboratory workflows, offering precision and adaptability for a wide range of applications. Whether as standalone units or integrated into larger workstations, these systems excel in automating both small and large volume experiments, accommodating various labware types from microplates to bottles. Their compact design allows them to fit seamlessly into standard lab settings, including fume hoods and biosafety cabinets, while minimizing errors and maximizing efficiency in complex liquid handling protocols.
With intuitive software integration and compatibility with over 200 third-party lab instruments, Hudson systems ensure comprehensive data tracking and regulatory compliance. Through user-friendly interfaces and guided operation technology, technicians can execute protocols seamlessly, even when encountering unfamiliar tasks.
SOLO Liquid Handler
The Hudson SOLO™ is an innovative automated pipettor, or liquid handling robot, designed to streamline liquid handling processes in research, pharmaceutical, and clinical laboratories. With its low cost, flexibility, and user-friendly interface, the SOLO offers unparalleled convenience and efficiency in pipetting tasks.
Available in single, 8, and 12 channel pipette options, the SOLO automated pipetting robot can be programmed to do anything expected of a hand-held pipettor, with greatly improved precision.
The SOLO can be loaded and operated manually, but is also compatible with robotic arms such as Hudson’s PlateCrane EX. The small footprint and open design of the SOLO automated pipettor provide easy integration with accessories, such as heating and cooling nests, incubators, magnetic bead nests, automatable centrifuges, microplate readers, and more.
Features
- Compact as small as 14″ x 16″ (355mm x 400mm) footprint for a 4 microplate position SOLO
- 8-, 24-, 96-, 384- and 1536-well microplate compatible
- Compatible with a wide variety of non-standard vials, test tubes and reagent reservoirs
- Broad volume range: 500nl to 1000ul for the multi-tip heads, 500nL to 10mL for the single-tip heads.
- Easily fits in a standard hood
- Fully compatible with robot loading systems or can be used manually as a stand alone unit
- Plate stacker upgrade available anytime for unparalleled flexibility and high throughput
- Easy to use SoloSoft control software for simple programming of automated pipetting steps
- Includes Hudson Robotics’ SoftLinx software, which provides an easy-to-use interface to coordinate the SOLO’s operation with other automated instruments
Specifications
| Dispensing | Single channel – 1ul to 10 ml; optional pump assembly for bulk dispensing8 & 12 channel : 1-10 ul pipette head; 5 – 200ul pipette head; 20 – 1000 ul pipette head |
| Plate Capacity | 4, 6, 8, 10,12 microplate positions available |
| Optional Microplate Gripper | Move plates to accessories on the deck or other instruments |
| Plate Format | SBS standard footprint, any well configuration; enquire about custom nests |
| Tubes, Flasks and Vials | Any format |
| Housing material | Stainless steel main deck; painted steel upper arm covers over machined aluminium structural components |
| Spill Protection | All electronics protected by solid, non-penetrated cover to prevent any leakage onto electrical devices |
| Arm Mechanism | Horizontal Travel/Vertical Stroke: x=57 cm y=24 cm; z=10 cm |
| Size | 61 cm x 75 cm x 50 cm (H x W x D) for a 4 microplate position SOLO |
| Weight | 23kg |
| Power Requirements | 120-240 VAC, 50-60Hz, 2Amps Max at 120 |
| Computer Interface | RS-232 serial cable |
| Precision | 20-200uL CV < 2%>200uL CV < 5% |
| Speed |
Average timings based on filling each well of a 96 well plate with 5uL of liquid, one well at a time:Aspirate from a reservoir (Same point each time) 1.43 mins Copy plate – well by well with no tip changes 6.18 mins Copy plate – well by well with 96 tip changes 29.04 mins |
Micro10x™ Reagent Dispenser
Hudson’s Micro10x™ Reagent Dispenser provides a combination of fast filling speeds, high accuracy, and extreme flexibility ordinarily found only among large, expensive liquid handling robots. It has a very small footprint saving bench space. The Micro10x accurately dispenses liquids in volumes down to low microliter range and is the only small dispenser capable of tip-touch off to ensure a clean dispense of high surface-tension fluids. Its positive-displacement pump head is adjustable in increments of 10nL, and never requires recalibration. The pump is available in two different sizes (0.25″ or 0.375″ barrel) to maximize accuracy at low and high volumes. The Micro10x microplate dispenser can be used as a standalone laboratory instrument or integrated into laboratory workstation.
Features
- Auto Priming to allow priming at programmed intervals
- Self-draining prime trough allows repeated priming without undesirable overflows or manual emptying
- Equipped with a small, highly responsive, touch screen pendant with an easy-to-read colour display. Comes with a positive mounting bracket on the base unit.
- Up to 20 Dispense programs, and 10 Priming programs stored internally
- Full RS-232 external control capability for easy integration into robot systems
- In-Line operation with track systems, or stand-alone manual-loading
- Reversible pump for emptying the fluid path
- Pump available in two different sizes (0.25″ or 0.375″ barrel).
- Small footprint to conserve valuable bench space
- All electronics are well away from potential spill areas
- Up to 10 individually controlled fluid paths are available to dispense multiple reagents “on-the-fly”
- Available in either landscape (12-nozzle dispensing) or portrait (8-nozzle dispensing).
Specifications
| Precision | >5μL CV <3%3μL-5μL CV <5% |
| Pump Sizes | 0.25″ or 0.375″ barrel |
| Cleaning | Fully autovclavable |
| Dispensing | Landscape: 12-nozzle dispensingPortrait: 8-nozzle dispensing |
| Dispense Times for an entire plate (using 12-nozzle manifold, 50% pump speed) |
96 wells, 100uL per well, 13 seconds96 wells, 25uL per well, 9 seconds 384 wells, 25uL per well, 22 seconds 384 wells, 10uL per well, 18 seconds 1536 wells, 5uL per well, 63 seconds |
RapidWash Microplate Washer
The RapidWash™ high-speed microplate washer for 96-well and 384-well microplates offers high throughput washing for ELISAs, cellular assays, and other processes requiring washing and aspirating.
With its small footprint the RapidWash fits comfortably in all robotic work cells as well as laboratory benches. The Rapidwash can be used as a standalone microplate washer or it can be integrated it into Hudson designed workstations. A software API is available for integration into other schedulers or automation platforms. Combine the RapidWash with an automated pipettor, reagent dispenser, robotic arm and microplate stacks for hours of hands-off processing.
Applications
- ELISA (Enzyme-Linked ImmunoSorbent Assay)
- FIA (Fluorescent Immuno Assay)
- LIA (Luminescent Immuno Assay)
- Cytotoxicity Assays
- Agglutination Assays
Features
- Works with both low profile and deep well microplates
- High speed: less than 9 sec. 96-well fill/aspirate cycle
- Low residual volume: <2uL per well
- Programmable dispensing and aspiration rates
- Programmable nozzle insertion/exit rates
- Programmable residual volumes, with easy setup
- High precision: <1% @ 100uL per well, plate-to-plate
- Up to 2 wash buffer sources, automatically selectable
- Easy software integration with other instruments
- Open API for integration using 3rd party software
FilterPress™ DNA, and RNA, Extraction
The FilterPress™, a powerful alternative to vacuum nests, magnetic beads and centrifuges for the separation of a variety of materials. The main applications are DNA, RNA, plasmid and protein extraction and purification as well as solid-phase extractions.
The upper nest supports a wide range of filter/spin plates and SPE columns.
Any SBS format microplate can be used as a collection plate in the lower nest, and when empty, the nest acts as a waste trough.
Both the temperature and pressure of the air used to push fluids through the filter plates or columns are automatically controlled by software.
Both nests are accessible to the SOLO™ pipettor if placed by its side, and a Micro10x™ reagent dispenser can be included to add a wide variety of wash and elution buffers to the filter plate or column in the upper nest. The FilterPress™ is perfect for designing fully automated DNA extraction, RNA extraction and protein extraction workstations.
Applications
- DNA Extraction
- Solid Phase Extraction (SPE)
- Oligo Purification
- Protein Expression & Purification
Applications
- Immunoprecipitation
- Cell isolation
- Cell activation & expansion
- Nucleic acid isolation
- mRNA isolation with Oligo(dT)
- Exosome analysis
- Streptavidin Dynabeads: Isolate any biological entity
- IVD assay development
Magnetic Bead Station
The Hudson Magnetic Bead Station automates magnetic bead separation methods by raising or lowering a strong permanent magnet against the bottom of a standard or deepwell microplate.
By raising and lowering the magnet at appropriate points in a method, the entire process can be easily automated. Hudson Robotics can automate commercially available protocols using magnetic bead kits as well as proprietary protocols using magnetic beads.
When elevated, the magnet secures the magnetic beads along the well’s perimeter, creating a bead-free central zone. This design is optimal for the SOLO Liquid Handler to perform its tasks—accurately aspirating and dispensing buffers and wash reagents necessary for processes like purification and cleavage, without interference from the beads.
Conversely, lowering the magnet disperses the beads throughout the well, facilitating thorough mixing by the SOLO through re-pipetting actions.
This dynamic raise-and-lower mechanism enables the full automation of the separation process. Hudson Robotics not only supports the automation of existing magnetic bead protocols available commercially but also, custom protocols developed for specific research needs.
Available in configurations for 24, 96, or 384 well plates, these systems can be tailored for semi-automated or fully automated processes, adapting to a range of laboratory needs.
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