Focus of the MonthHTX Imaging SubliMATE™️: MALDI Imaging with Solvent-Free Matrix Deposition

9 June 2025by verulam

HTX SubliMATE™️: MALDI Imaging with Solvent-Free Matrix Deposition

 

The HTX SubliMATE is a robust and easy to use MALDI matrix deposition system for controlled, reproducible, sublimation of the smallest available matrix crystals for sub-micron resolution mass spectrometry imaging.

 

Using a fully integrated ceramic heater for consistent and quick heating, a range of MALDI matrices can be sublimated onto a maximum of 4 slides. The slides are then cooled to 15 to -78 oC to produce ultra small matrix crystals for sub-micron resolution mass spectrometry imaging.

 

What are the benefits of sublimation?

Improved Spatial Resolution: Sublimation provides minimum crystal size in the nanometer range.

 

Delocalization is minimised: By skipping the liquid phase in the matrix deposition process, more spatial information is preserved in samples.

 

Increased efficiency: The matrix layer can be applied in one single process before each sublimation cycle ensuring homogenous distribution of matrix crystals.

 

Key Features

  • Four slide capacity for increased throughput
  • Fast heating and cooling for quick sample preparation
  • Highly consistent matrix deposition across entire sample area
  • Proprietary Matrix Wafer template design for even distribution of matrix prior to sublimation
  • Validated protocols for most MALDI matrices (eg. CHCA, DAN, DHAP, DHB, NEDC)
  • Continuous matrix coverage as needed for high spatial resolution MALDI imaging

 

Discover more about the HTX SubliMATE: MALDI Imaging and Sample Prep – Verulam Scientific

 

Or contact Verulam Scientific to see how we can help you further.

📞 01234 381000

📩 [email protected]

🌐 https://verulamscientific.com/htx-imaging-solutions/#sublimator